CD Molecules Reference Guide

A comprehensive guide for pediatricians and medical students

T Cell Markers

CD1 Family (CD1a-e)

Function: Presents lipid and glycolipid antigens to T cells

Associated conditions: - Langerhans cell histiocytosis - Mycobacterial infections - Autoimmune disorders

CD2

Function: T cell adhesion molecule and activation signal

Associated conditions: - T cell lymphomas - Immunodeficiency disorders

CD3

Function: T cell receptor complex component essential for T cell activation

Associated conditions: - Severe Combined Immunodeficiency (SCID) - T cell lymphomas/leukemias - DiGeorge syndrome

CD4

Function: Co-receptor for MHC class II, T helper cell marker

Associated conditions: - HIV infection - Immunodeficiency disorders - Helper T cell lymphomas

CD Molecules 1-25: Comprehensive Reference

CD1 (a-e)

Function: Present lipid and glycolipid antigens to T cells
- CD1a: Expressed on Langerhans cells and cortical thymocytes
- CD1b: Found on dendritic cells
- CD1c: Present on B cells and dendritic cells
- CD1d: Presents lipids to NKT cells
- CD1e: Intracellular protein aiding lipid loading

Associated conditions: - Langerhans cell histiocytosis - Contact hypersensitivity - Mycobacterial infections

CD2

Function: Adhesion molecule found on T cells and NK cells; binds to CD58

Clinical significance: - T-cell lymphomas - Used in targeted therapy for GVHD - Immunodeficiency disorders

CD3

Function: T cell receptor complex component; essential for T cell signal transduction

Clinical significance: - SCID diagnosis - T-cell lymphoma/leukemia marker - DiGeorge syndrome diagnosis

CD4

Function: Co-receptor for MHC class II molecules; defines T helper cells

Clinical significance: - HIV infection monitoring - CD4+ T-cell lymphomas - Immunodeficiency evaluation

CD5

Function: T cell and B1 B cell marker; regulates lymphocyte signaling

Clinical significance: - CLL diagnosis - Mantle cell lymphoma - Autoimmune diseases

CD6

Function: T cell costimulatory molecule; binds to CD166

Clinical significance: - Multiple sclerosis treatment target - Rheumatoid arthritis - T cell lymphomas

CD7

Function: Early T cell marker; involved in T cell development and activation

Clinical significance: - T-cell acute lymphoblastic leukemia - T-cell lymphoma diagnosis - NK cell neoplasms

CD8

Function: Co-receptor for MHC class I molecules; defines cytotoxic T cells

Clinical significance: - Viral infection monitoring - CD8+ T-cell lymphomas - Autoimmune diseases

CD9

Function: Tetraspanin family; involved in cell adhesion and migration

Clinical significance: - Acute lymphoblastic leukemia - Platelet function - Fertility issues

CD10

Function: Neutral endopeptidase; common acute lymphoblastic leukemia antigen (CALLA)

Clinical significance: - B-ALL classification - Follicular lymphoma - Burkitt lymphoma

CD11a

Function: Alpha subunit of LFA-1; important for leukocyte adhesion

Clinical significance: - Leukocyte adhesion deficiency - Inflammatory conditions - Autoimmune diseases

CD11b

Function: Integrin alpha M; expressed on myeloid cells and NK cells

Clinical significance: - Acute myeloid leukemia - Inflammatory diseases - Phagocyte disorders

CD11c

Function: Integrin alpha X; dendritic cell marker

Clinical significance: - Hairy cell leukemia - Dendritic cell disorders - Myeloid neoplasms

CD13

Function: Aminopeptidase N; myeloid cell marker

Clinical significance: - Acute myeloid leukemia - Myeloproliferative disorders - Drug metabolism

CD14

Function: LPS receptor; monocyte/macrophage marker

Clinical significance: - Sepsis monitoring - Inflammatory diseases - Innate immunity disorders

CD15

Function: Lewis X antigen; granulocyte marker

Clinical significance: - Hodgkin lymphoma - Reed-Sternberg cells - Neutrophil disorders

CD16

Function: Fc gamma RIII; NK cells and neutrophils marker

Clinical significance: - NK cell deficiency - ADCC monitoring - Autoimmune neutropenia

CD17

Function: Lactosylceramide; found on neutrophils and monocytes

Clinical significance: - Fungal infection response - Neutrophil activation - Inflammatory diseases

CD18

Function: Beta-2 integrin; partners with CD11 molecules

Clinical significance: - Leukocyte adhesion deficiency - Inflammatory responses - Wound healing disorders

CD19

Function: B cell co-receptor; essential for B cell development

Clinical significance: - B-cell lymphomas - CAR-T cell therapy target - CVID diagnosis

CD20

Function: B cell differentiation protein; calcium channel

Clinical significance: - Rituximab target - B-cell lymphomas - Multiple sclerosis

CD21

Function: Complement receptor 2; EBV receptor on B cells

Clinical significance: - EBV infection - B-cell disorders - Complement deficiencies

CD22

Function: B cell-specific adhesion molecule; regulates B cell activation

Clinical significance: - B-ALL treatment target - Autoimmune diseases - B-cell lymphomas

CD23

Function: Low-affinity IgE receptor; B cell activation marker

Clinical significance: - CLL diagnosis - Allergic disorders - B-cell disorders

CD24

Function: B cell differentiation marker; granulocyte signal transducer

Clinical significance: - B-cell neoplasms - Autoimmune diseases - Cancer stem cells

CD25

Function: IL-2 receptor alpha chain; activated T cell marker

Clinical significance: - HTLV-1 infection - Regulatory T cell marker - Immunotherapy monitoring

CD Molecules 26-50: Comprehensive Reference

CD26

Function: Dipeptidyl peptidase IV; T cell activation antigen

Clinical significance: - Type 2 diabetes (DPP4 inhibitor target) - T-cell lymphomas - COVID-19 receptor

CD27

Function: TNF receptor family; memory B cell marker

Clinical significance: - Multiple myeloma - Memory B cell deficiency - EBV-associated lymphoproliferative disorders

CD28

Function: T cell costimulatory receptor; binds CD80/CD86

Clinical significance: - Autoimmune diseases - Cancer immunotherapy - Immunodeficiency disorders

CD29

Function: Beta-1 integrin; cell adhesion and migration

Clinical significance: - Platelet disorders - Metastatic disease - Wound healing defects

CD30

Function: TNF receptor family; activated lymphocyte marker

Clinical significance: - Hodgkin lymphoma - Anaplastic large cell lymphoma - Immunotherapy target

CD31

Function: PECAM-1; endothelial cell adhesion molecule

Clinical significance: - Vasculitis - Atherosclerosis - Angiogenesis disorders

CD32

Function: Fc gamma RII; low-affinity IgG receptor

Clinical significance: - Autoimmune thrombocytopenia - Kawasaki disease - Immune complex disorders

CD33

Function: Sialic acid-binding lectin; myeloid marker

Clinical significance: - AML treatment target - Myelodysplastic syndrome - CAR-T cell therapy

CD34

Function: Hematopoietic stem cell marker; adhesion molecule

Clinical significance: - Stem cell enumeration - Leukemia diagnosis - Vascular tumors

CD35

Function: Complement receptor 1; immune complex clearance

Clinical significance: - Systemic lupus erythematosus - Malaria susceptibility - Complement deficiencies

CD36

Function: Scavenger receptor; fatty acid translocase

Clinical significance: - Platelet disorders - Malaria infection - Metabolic disorders

CD37

Function: Tetraspanin family; B cell organization

Clinical significance: - B-cell lymphomas - Immunodeficiency - Novel therapeutic target

CD38

Function: NAD+ glycohydrolase; lymphocyte activation

Clinical significance: - Multiple myeloma target - CLL prognosis - HIV disease progression

CD39

Function: Ectonucleotidase; regulatory T cell marker

Clinical significance: - Autoimmune diseases - Cancer immunotherapy - Inflammatory disorders

CD40

Function: TNF receptor family; B cell costimulation

Clinical significance: - Hyper-IgM syndrome - Autoimmune diseases - Cancer immunotherapy

CD41

Function: Integrin alpha-IIb; platelet glycoprotein

Clinical significance: - Glanzmann thrombasthenia - Platelet disorders - Megakaryoblastic leukemia

CD42

Function: Platelet glycoprotein complex (a-d)

Clinical significance: - Bernard-Soulier syndrome - Platelet function defects - von Willebrand disease

CD43

Function: Sialophorin; leukocyte surface mucin

Clinical significance: - Wiskott-Aldrich syndrome - T-cell lymphomas - Neutrophil function

CD44

Function: Hyaluronic acid receptor; cell adhesion

Clinical significance: - Cancer metastasis - Inflammation - Stem cell marker

CD45

Function: Leukocyte common antigen; protein tyrosine phosphatase

Clinical significance: - SCID diagnosis - Leukemia/lymphoma typing - Immunodeficiency disorders

CD46

Function: Complement regulatory protein; pathogen receptor

Clinical significance: - Measles virus receptor - Complement disorders - Reproductive failure

CD47

Function: Integrin-associated protein; "don't eat me" signal

Clinical significance: - Cancer immunotherapy target - Autoimmune diseases - Red cell disorders

CD48

Function: CD2 ligand; lymphocyte activation

Clinical significance: - X-linked lymphoproliferative disease - Immune response regulation - B-cell disorders

CD49

Function: Integrin alpha subunits (a-f); cell adhesion

Clinical significance: - Autoimmune diseases - Cancer metastasis - Inflammatory disorders

CD50

Function: ICAM-3; leukocyte adhesion molecule

Clinical significance: - Immune response regulation - Dendritic cell function - Inflammatory diseases

CD Molecules 51-75: Comprehensive Reference

CD51

Function: Integrin alpha V; vitronectin receptor

Clinical significance: - Angiogenesis disorders - Osteoporosis - Cancer metastasis

CD52

Function: CAMPATH-1 antigen; lymphocyte glycoprotein

Clinical significance: - CLL treatment target (alemtuzumab) - Multiple sclerosis - Graft-versus-host disease

CD53

Function: Tetraspanin family; signal transduction

Clinical significance: - Immunodeficiency - B-cell development - Inflammatory responses

CD54

Function: ICAM-1; intercellular adhesion molecule

Clinical significance: - Inflammatory diseases - Atherosclerosis - Rhinovirus receptor

CD55

Function: Decay accelerating factor; complement regulation

Clinical significance: - PNH diagnosis - Complement disorders - Autoimmune diseases

CD56

Function: NCAM; neural cell adhesion molecule

Clinical significance: - NK cell identification - Multiple myeloma - Small cell lung cancer

CD57

Function: HNK-1; NK cell marker

Clinical significance: - Chronic viral infections - T cell senescence - NK cell lymphomas

CD58

Function: LFA-3; CD2 ligand

Clinical significance: - T cell activation disorders - Immune response regulation - Inflammatory conditions

CD59

Function: Protectin; complement regulation

Clinical significance: - PNH diagnosis - Complement disorders - Hemolytic anemia

CD60

Function: GD3 ganglioside derivatives

Clinical significance: - T cell activation - Neural development - Melanoma marker

CD61

Function: Integrin beta-3; platelet glycoprotein

Clinical significance: - Glanzmann thrombasthenia - Platelet disorders - Neonatal alloimmune thrombocytopenia

CD62

Function: Selectin family (L, E, P); adhesion molecules

Clinical significance: - Inflammatory diseases - Leukocyte trafficking - Vascular disorders

CD63

Function: Tetraspanin; lysosomal protein

Clinical significance: - Platelet activation - Allergic responses - Cancer progression

CD64

Function: High-affinity Fc gamma RI

Clinical significance: - Sepsis diagnosis - Autoimmune disorders - Myeloid cell activation

CD65

Function: Carbohydrate antigen; myeloid differentiation

Clinical significance: - AML diagnosis - Myeloid differentiation - Inflammatory responses

CD66

Function: CEA family; cell adhesion molecules

Clinical significance: - Colorectal cancer - Neutrophil activation - Bacterial infections

CD67

Function: CGM1; granulocyte marker

Clinical significance: - Neutrophil disorders - Inflammatory diseases - Myeloid cell development

CD68

Function: Macrophage marker; lysosomal glycoprotein

Clinical significance: - Histiocytic disorders - Tumor-associated macrophages - Inflammatory diseases

CD69

Function: Early activation antigen

Clinical significance: - Lymphocyte activation - Immune monitoring - Inflammatory responses

CD70

Function: TNF ligand family; CD27 ligand

Clinical significance: - Cancer immunotherapy - Autoimmune diseases - Viral infections

CD71

Function: Transferrin receptor

Clinical significance: - Iron deficiency anemia - Erythroid precursor identification - Cancer proliferation

CD72

Function: B cell co-receptor; negative regulator

Clinical significance: - Autoimmune diseases - B cell development - Immunodeficiency

CD73

Function: Ecto-5'-nucleotidase; adenosine production

Clinical significance: - Cancer immunotherapy - Immune suppression - Vascular permeability

CD74

Function: MHC class II chaperone; invariant chain

Clinical significance: - B-cell lymphomas - Autoimmune diseases - Antigen presentation disorders

CD75

Function: Sialic acid-containing glycoconjugates

Clinical significance: - B-cell lymphomas - Cell differentiation - Immune regulation

CD Molecules 76-100: Comprehensive Reference

CD76

Function: B cell surface glycoprotein; tetraspanin family

Clinical significance: - B cell development - Lymphoid malignancies - Cell signaling disorders

CD77

Function: Globotriaosylceramide; Burkitt's lymphoma antigen

Clinical significance: - Burkitt's lymphoma - Germinal center B cells - Verotoxin receptor

CD78

Function: B cell-specific protein

Clinical significance: - B cell development - Lymphoid disorders - Immune response regulation

CD79

Function: B cell receptor complex (a/b); Ig alpha/beta

Clinical significance: - B cell lymphomas - Agammaglobulinemia - B cell development disorders

CD80

Function: B7-1; T cell costimulation molecule

Clinical significance: - Autoimmune diseases - Cancer immunotherapy - Transplant rejection

CD81

Function: TAPA-1; tetraspanin family

Clinical significance: - Hepatitis C virus receptor - B cell signaling - Immune synapse formation

CD82

Function: Metastasis suppressor; tetraspanin family

Clinical significance: - Cancer metastasis - T cell activation - Signal transduction

CD83

Function: Dendritic cell maturation marker

Clinical significance: - Immune regulation - Dendritic cell function - Inflammatory responses

CD84

Function: SLAM family; immune regulation

Clinical significance: - Platelet function - T cell responses - Immune system disorders

CD85

Function: ILT family; immunoglobulin-like transcripts

Clinical significance: - Immune regulation - NK cell function - Autoimmune diseases

CD86

Function: B7-2; T cell costimulation molecule

Clinical significance: - Autoimmune diseases - Transplant rejection - Cancer immunotherapy

CD87

Function: uPAR; plasminogen activation

Clinical significance: - Cancer invasion - Inflammatory diseases - Tissue remodeling

CD88

Function: C5a receptor; complement signaling

Clinical significance: - Inflammatory diseases - Sepsis - Complement disorders

CD89

Function: Fc alpha receptor; IgA receptor

Clinical significance: - Mucosal immunity - IgA nephropathy - Inflammatory bowel disease

CD90

Function: Thy-1; stem cell marker

Clinical significance: - Cancer stem cells - Fibrosis - Neurological disorders

CD91

Function: LRP1; alpha-2-macroglobulin receptor

Clinical significance: - Atherosclerosis - Alzheimer's disease - Tissue remodeling

CD92

Function: Choline transporter-like protein 1

Clinical significance: - Cell activation - Membrane transport - Cellular metabolism

CD93

Function: C1qRp; phagocytosis and clearance

Clinical significance: - Angiogenesis - Inflammation - Innate immunity

CD94

Function: NK cell receptor; partners with NKG2

Clinical significance: - NK cell function - Viral infections - Cancer immunity

CD95

Function: Fas; death receptor

Clinical significance: - Autoimmune lymphoproliferative syndrome - Cancer therapy - Apoptosis disorders

CD96

Function: TACTILE; NK cell receptor

Clinical significance: - Cancer immunotherapy - NK cell function - Immune surveillance

CD97

Function: Adhesion G protein-coupled receptor

Clinical significance: - Inflammatory diseases - Cancer progression - Immune cell migration

CD98

Function: Amino acid transport; cell fusion

Clinical significance: - Cancer metabolism - T cell activation - Amino acid transport disorders

CD99

Function: MIC2; leukocyte migration

Clinical significance: - Ewing sarcoma - Leukocyte trafficking - T cell development

CD100

Function: Semaphorin 4D; immune regulation

Clinical significance: - Multiple sclerosis - Cancer progression - Immune cell migration

CD101

Function: Immunoglobulin superfamily member; T cell regulation

Clinical significance: - Allergic responses - Myeloid cell function - Inflammatory diseases

CD102

Function: ICAM-2; adhesion molecule

Clinical significance: - Leukocyte trafficking - Angiogenesis - Inflammatory disorders

CD103

Function: Integrin αE; mucosal lymphocyte adhesion

Clinical significance: - Mucosal immunity - Tissue-resident T cells - Inflammatory bowel disease

CD104

Function: Integrin β4; epithelial adhesion

Clinical significance: - Epidermolysis bullosa - Cancer progression - Wound healing

CD105

Function: Endoglin; TGF-β receptor complex

Clinical significance: - Hereditary hemorrhagic telangiectasia - Tumor angiogenesis - Cardiovascular development

CD106

Function: VCAM-1; vascular adhesion molecule

Clinical significance: - Atherosclerosis - Inflammatory diseases - Leukocyte trafficking

CD107

Function: LAMP-1; lysosomal membrane protein

Clinical significance: - NK cell degranulation - Cytotoxic T cell function - Lysosomal disorders

CD108

Function: Semaphorin-7A; immune regulation

Clinical significance: - T cell responses - Axon guidance - Inflammatory responses

CD109

Function: TGF-β co-receptor; GPI-linked protein

Clinical significance: - Cancer progression - Fibrosis - Wound healing

CD110

Function: Thrombopoietin receptor; MPL

Clinical significance: - Thrombocytopenia - Myeloproliferative disorders - Platelet production

CD111

Function: Nectin-1; adhesion molecule

Clinical significance: - Herpes virus entry - Synaptic formation - Neural development

CD112

Function: Nectin-2; viral receptor

Clinical significance: - NK cell recognition - Viral infections - Immune surveillance

CD113

Function: Nectin-3; cell adhesion

Clinical significance: - Neural development - Synapse formation - Cell-cell interactions

CD114

Function: G-CSF receptor; granulopoiesis

Clinical significance: - Neutropenia - Myeloid disorders - Infection susceptibility

CD115

Function: M-CSF receptor; macrophage development

Clinical significance: - Osteopetrosis - Macrophage disorders - Inflammatory diseases

CD116

Function: GM-CSF receptor alpha chain

Clinical significance: - Pulmonary alveolar proteinosis - Myeloid development - Inflammatory responses

CD117

Function: c-Kit; stem cell factor receptor

Clinical significance: - GIST tumors - Mastocytosis - Hematopoietic disorders

CD118

Function: Interferon alpha/beta receptor

Clinical significance: - Viral infections - Autoimmune diseases - Cancer immunotherapy

CD119

Function: Interferon gamma receptor

Clinical significance: - Mycobacterial infections - Immune deficiency - Inflammatory diseases

CD120

Function: TNF receptor (a/b)

Clinical significance: - Inflammatory diseases - Autoimmune disorders - Cancer therapy

CD121

Function: IL-1 receptor (a/b)

Clinical significance: - Autoinflammatory diseases - Fever syndromes - Inflammatory responses

CD122

Function: IL-2 receptor beta chain

Clinical significance: - T cell development - NK cell function - Immunodeficiency

CD123

Function: IL-3 receptor alpha chain

Clinical significance: - Acute myeloid leukemia - Basophil development - Allergic responses

CD124

Function: IL-4 receptor alpha chain

Clinical significance: - Allergic diseases - IgE production - Th2 responses

CD125

Function: IL-5 receptor alpha chain

Clinical significance: - Eosinophilic disorders - Asthma - Allergic inflammation